| Route | Terminal A | Serves | Terminal B | Notes and history |
| M1 | Chicago, IL | | Ann Arbor, MI or
Detroit, MI | - Service began on April 10, 2006.
- Ann Arbor added on April 2, 2007.
- Passengers are carried to and from Chicago only.
|
| M3 | Chicago, IL | Toledo, OH | Cleveland, OH | - Service began on April 10, 2006.
- Toledo, OH added on September 11, 2006.
- Pittsburgh, PA added April 2, 2007; initially withdrawn on September 16, 2007 due to insufficient ridership.
Restored on route M45 in 2011. |
M4
M4A | Chicago, IL | Milwaukee (M4A) or
Madison (M4) | Minneapolis, MN | - Service began on April 10, 2006.
- Minneapolis, MN added on April 2, 2007. Madison, WI added on March 13, 2008.
- Service is not available wholly within Wisconsin.
|
| M5 | Chicago, IL | - Normal, IL
- St. Louis, MO
- Columbia, MO
| Kansas City, MO | - Service began on April 10, 2006
- Kansas City, MO added on April 2, 2007.
- Columbia added on March 13, 2008.
- Columbia and Normal are not served on the same trip.
|
M6
M6A M6B | Chicago, IL | Indianapolis, IN | Columbus, OH (M6A or M6B) or
Cincinnati, OH (M6A) | - Service began on April 10, 2006. Overnight trips serve both terminals.
- Columbus, OH withdrawn June 4, 2006 due to low ridership. Reinstated on April 2, 2007.
- Louisville, Kentucky withdrawn September 16, 2007 due to low ridership.
|
| M7 | Chicago, IL | Champaign, IL | Memphis, TN | - Service began on March 27, 2008.
|
M8
M8A | Chicago, IL | Iowa City, IA | Des Moines, IA (M8) or
Omaha, NE (M8A) | - Service began on May 4, 2010
- Service with two of four continuing to Omaha, began August 17, 2011.
|
| M20 | New York, NY | Providence, RI | Hyannis, MA | - Providence added in 2010. Providence is a standalone line. NY-Boston runs do not stop in Providence.
|
| M21 | New York, NY | Baltimore, MD | Washington, D.C. | - Service began on May 30, 2008.
- Passengers are carried to and from New York City only.
- Early morning AM trip from New York are interlined with the M31 service.
- Customers traveling between Baltimore and Washington D.C. must use the M31.
|
| M22 | New York, NY | | Boston, MA | - Operated by DATTCO under contract to Coach USA (using both Coach USA-owned and DATTCO-owned equipment).
- Service began on May 30, 2008.
- Hartford added December 4, 2008, but withdrawn on September 14, 2009.[14]
- NY-Boston runs do not stop in Providence. NY-PROV runs are designated as M20.
|
| M23 | New York, NY | | Philadelphia, PA | - Service began on May 30, 2008.
|
M24
M26 | New York, NY | - Syracuse
- Victor (Rochester)
- Buffalo (downtown and airport)
| Toronto, ON | - Service began on May 30, 2008. Syracuse and Rochester local service began on December 4, 2008.
- Binghamton was added on June 6, 2008, but withdrawn on December 3, 2008 because of low ridership.
- Niagara Falls, Ontario was added on December 4, 2008, but withdrawn on June 28, 2009 due to low ridership.
|
| M25 | New York, NY | | Atlantic City, NJ | - Operated by Academy Bus. Wi-Fi is not available on this route.
- Only round-trip fares are sold.
|
| M27 | New York, NY | Ridgewood, NJ | Rensselaer (Albany, NY)Saratoga Springs, NY | - Service began on December 4, 2008.
- Passengers are carried to and from Albany-Rensselaer only.
- Saratoga Springs service begins April 2, 2012.
|
| M28 | New York, NY | State College, PA | Pittsburgh, PA | - Service began on May 4, 2010.
|
| M29 | Pittsburgh, PA | | Philadelphia, PA | - Service began on July 21, 2010
- Camden service withdrawn
|
| M30 | Philadelphia, PA | Harrisburg, PA | State College, PA | - Three daily round trips
- Camden service withdrawn
- No local passengers carried between Camden and Philadelphia.
|
| M31 | Philadelphia, PA | Baltimore, MD
Washington, D.C.
Richmond, VA | Hampton, VA | - Eight weekday round trips.
- Local passengers may be carried between Washington and Baltimore on the M31 line.
- Some trips are interlined with M21 trips.
|
| M32 | Philadelphia, PA | Secaucus, NJ | Boston, MA | |
| M34 | Philadelphia, PA | - Syracuse
- Buffalo (downtown and airport)
| Toronto, ON | - Two round trips, only one of which serves the Buffalo Niagara Airport.
|
| M35 | New York, NY | Hartford, CT | Amherst, MA | - Service began on December 15, 2010.
|
| M36 | Pittsburgh, PA | - Frederick, MD or
- Morgantown, WV
| Washington, D.C. | - Service began on December 15, 2010
- Frederick service added May 11, 2011
- Morgantown service added on January 12, 2012
- Morgantown and Frederick are not served on same trips.
|
| M37 | Washington, D.C. | - Richmond, VA
- Raleigh/Durham, NC
| Charlotte, NC | |
| M38 | Washington, D.C. | Christiansburg, VA | Knoxville, TN | |
| M42 | Washington, D.C. | Baltimore, MD
Secaucus, NJPhiladelphia, PA | Boston, MA | |
| M44 | Washington, D.C. | Baltimore, MD
Harrisburg, PA
Buffalo, NY | Toronto, ON | |
| M45 | Pittsburgh, PA | | Cleveland, OH | - Service began May 11, 2011
- Service being discontinued on March 14, 2012 due to low ridership.
|
| M46 | Pittsburgh, PA | | Detroit, MI | - Service began May 11, 2011
- Cleveland, OH added January 4, 2012
- Ann Arbor, MI will be added as final destination starting March 14, 2012
|
| M47 | Pittsburgh, PA | | Cincinnati, OH | - Service began May 11, 2011.
- Service being discontinued on March 14, 2012 due to low ridership.
|
| M51 | Boston, MA | Hartford, CT | New Haven, CT | - Service began August 17, 2011.
|
| M53 | Boston, MA | | Burlington, VT | - Service began August 17, 2011.
|
| M64 | Pittsburgh, PA | | Toronto, ON | - Service began May 11, 2011
- Service being discontinued on March 14, 2012 due to low ridership.
|
| M91 | Atlanta, GA | Chattanooga, TN | Knoxville, TN | - Service began November 16, 2011
|
| M92 | Atlanta, GA | Chattanooga, TN | Nashville, TN | - Service began November 16, 2011
|
| M93 | Atlanta, GA | Birmingham, AL | Memphis, TN | - Service began November 16, 2011
|
| M94 | Atlanta, GA | Montgomery, AL | Mobile, ALNew Orleans, LA | - Service began November 16, 2011
- Service extends to New Orleans on April 2, 2012
|
| M95 | Atlanta, GA | | Charlotte, NC | - Service began November 16, 2011
|
| M96 | Atlanta, GA | Jacksonville, FL
or
Gainesville, FL | Orlando, FL | - Service began November 16, 2011
|
TOR-
MTL | Toronto | Kingston, ON | Montreal | - Various pickup points within the Greater Toronto Area and on the Island of Montreal only for travel to Kingston and beyond.
|
